Please see the podcast below. It is an interview (on NPR's Fresh Air) with Charles Mann, the author of the most recent book on how the exchange of plants, animals, and microbes radically changed the course of history for both the Old World and the New World. It's a great example of how unitended consequences are often even more important than intended consequences.
Of course history ofetn informs (or misinforms) and inspires art - here's an example in Neil Young's "Cortez the Killer."
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